Dr. Sepe earned his Bachelor of Science degree in Biochemistry/Molecular Biology at Brown University and his Medical Doctorate from Harvard Medical School. He completed an Internal Medicine residency at Massachusetts General Hospital and a Gastroenterology Fellowship and an Advanced Endoscopy Fellowship at Beth Israel Deaconess Medical Center and Harvard Medical School. He has performed clinical research in Gastrointestinal Cancer and also has special interest in general Gastroenterology, pancreas and bile duct disease, and therapeutic endoscopy, including endoscopic ultrasound and endoscopic retrograde cholangiopancreatography (ERCP).

He is board certified in Internal Medicine and Gastroenterology and is a member of the Massachusetts Medical Society, American Gastroenterological Association, American College of Gastroenterology and the American Society for Gastrointestinal Endoscopy.